AKT1 E17K mutant is phosphorylated by TORC2 complex Authored: Orlic-Milacic, M, 2012-07-18 EC Number: 2.7.11 Edited: Matthews, L, 2012-08-03 PIP2-binding AKT1 E17K mutants are anchored to the plasma membrane in the absence of PI3K activity and are constitutively phosphorylated on serine S473, presumably by the TORC2 complex (Carpten et al. 2007, Landgraf et al. 2008). Pubmed17611497 Pubmed18954143 Reactome Database ID Release 432243938 Reactome, http://www.reactome.org ReactomeREACT_147858 Reviewed: Thorpe, Lauren, 2012-08-13 Reviewed: Yuzugullu, Haluk, 2012-08-13 Reviewed: Zhao, Jean J, 2012-08-13 AKT1 E17K mutant:PIP2 p-S473-AKT1 E17K mutant:PIP2