phenylpyruvate + NADH + H+ => phenyllactate + NAD+ Authored: D'Eustachio, P, 2012-03-04 Edited: D'Eustachio, P, 2012-03-16 Pubmed15421980 Reactome Database ID Release 432160489 Reactome, http://www.reactome.org ReactomeREACT_121215 Reviewed: Jassal, B, 2012-03-16 The ability of human lactate dehydrogenase to catalyze the reaction of phenylalanine with NADH + H+ to form phenyllactate and NAD+ is inferred from the properties of bovine heart lactate dehydrogenase (Meister 1951). As these studies were carried out only on the one bovine isoform, the reaction is inferred only for the corresponding human isoform. The reaction rate measured for bovine LDHB acting on phenylpyruvate is approximately 2% of its rate on pyruvate, but could yield appreciable amounts of phenyllactate under conditions of high phenylpyruvate concentration.