Hydrolysis of choloyl-CoA to cholate and CoASH Authored: D'Eustachio, P, 2007-02-17 19:40:28 Choloyl-CoA and water react to form cholate and CoASH. This reaction, catalyzed by acyl-coenzyme A thioesterase 8, occurs in the peroxisomal matrix (Jones et al. 1999; Hunt et al. 2002). While bile salts are the major product of the de novo biosynthetic pathway in the normal human liver, bile acids are major feedback regulators of this pathway and this hydrolysis reaction is thought to play a role in generating them (Russell 2003). Edited: D'Eustachio, P, 2007-02-17 19:40:28 Pubmed10092594 Pubmed11673457 Pubmed12543708 Reactome Database ID Release 43193385 Reactome, http://www.reactome.org ReactomeREACT_10061 Reviewed: D'Eustachio, P, 2007-04-30 14:43:26