THCA [mitochondrial matrix] => THCA [cytosol] Authored: Jassal, B, 2007-01-19 10:34:59 Edited: D'Eustachio, P, 2007-02-17 19:40:28 Pubmed11980911 Pubmed12543708 Reactome Database ID Release 43191971 Reactome, http://www.reactome.org ReactomeREACT_10089 Reviewed: D'Eustachio, P, 2007-04-30 14:43:26 THCA (3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate) is translocated from the mitochondrial matrix to the cytosol. The transporter that mediates its passage across the inner mitochondrial membrane has not been identified. In particular, despite the structural and functional similarities between THCA and long chain fatty acids, searches for carnitine - THCA have failed (Russell 2003). VLCS (SLC27A2), one of the enzymes that catalyzes CoA conjugation of THCA may also be present in peroxisomes, and Mihalik et al. (2002) have hypothesized that THCA could be translocated unchanged from the mitochondrial matrix to the peroxisomal matrix and undergo conjugation there. THCA is translocated from the mitochondrial matrix to the cytosol