NPC1L1 inactivation by ezetimibe Authored: D'Eustachio, P, 2008-05-12 17:46:52 Edited: D'Eustachio, P, 2008-06-13 14:03:50 Human NPC1L1, associated with the plasma membrane, binds ezetimibe and becomes incapable of mediating cholesterol uptake. The molecular mechanisms of cholesterol transport and ezetimibe inhibition, however, remain unclear (Garcia-Calvo et al. 2005; Weinglass et al. 2008). NPC1L1 + ezetimibe => NPC1L1:ezetimibe complex Pubmed15928087 Pubmed18187582 Reactome Database ID Release 43265456 Reactome, http://www.reactome.org ReactomeREACT_13435 Reviewed: Jassal, B, 2008-06-13 14:05:49 NPC1L1:ezetimibe complex