PAMP:NOD oligomer:K63-polyUb-RIP2:NEMO K63-polyubiquitin PAMP:NOD oligomer:RIP2:NEMO A20 deubiquitinates RIP2 Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Pubmed1381359 Pubmed16418393 Pubmed18079694 Pubmed18342009 Reactome Database ID Release 43688136 Reactome, http://www.reactome.org ReactomeREACT_75888 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06 The deubiquitinase A20 is a negative feedback regulator of inflammatory responses, induced by NFkappaB activation (Krikos et al. 1992) and NOD stimulation (Masumoto et al. 2006). A20 can deubiquitinate RIP2 and restricts NOD2 induced signals (Hitosumatsu et al. 2008). has a Stoichiometric coefficient of 6