PAMP:NOD oligomer:RIP2 PAMP:NOD oligomer:RIP2:NEMO RIP2 binds NEMO An intermediate region located between the CARD and kinase domains mediates the interaction of RIP2 with the IKK complex regulatory subunit NEMO. This interaction is presumed to link NOD1:RIP2 to the IKK complex, ultimately leading to the phosphorylation of IkappaB-alpha and the activation of NF-kappaB (Inohara et al. 2000). Although every NOD molecule in the oligomeric complex is represented as binding RIP2, binding to every member of the complex may not be required for subsequent signaling events. Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Pubmed18079694 Reactome Database ID Release 43622415 Reactome, http://www.reactome.org ReactomeREACT_75893 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06