NOD1:iE-DAP oligomer NOD1:iE-DAP Activated NOD1 oligomerizes Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 NOD1 is activated by iE-DAP in a LRR domain dependent manner. The LRR domain has a negative influence on NOD1 self-association (Inohara et al. 2000); binding of iE-DAP likely causes conformational changes that free the NACHT domain, allowing oligomerization and subsequent association of other proteins. Coimmunoprecipitation experiments demonstrate that NOD1 can interact with itself (Inohara et al. 1999) via the NACHT domain (Inohara et al. 2000). NACHT domains are part of the AAA+ domain family. Members of this family form hexamers or heptamers. Based on this observation, NOD1 and NOD2 are believed to form oligomers of this size (Martinon & Tschopp, 2005). Pubmed10329646 Pubmed10880512 Pubmed15967716 Reactome Database ID Release 43622310 Reactome, http://www.reactome.org ReactomeREACT_75809 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06 has a Stoichiometric coefficient of 6