NLRP3 elicitors:NLRP3 oligomer:ASC ASC is recruited via a PYD-PYD interaction Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 NLRP3 interacts with ASC (Manji et al. 2003) via their PYD domains (Dowds et al. 2004). NLRP3 oligomerization leads to PYD domain clustering which is believed to facilitate the interaction of NLRP3 with the PYD domain of ASC (Schroder & Tschopp, 2010). Pubmed11786556 Pubmed12615073 Pubmed20303873 Reactome Database ID Release 43844610 Reactome, http://www.reactome.org ReactomeREACT_75848 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06 NLRP3 elicitors:NLRP3 oligomer