Pyrin trimer:ASC Pyrin trimer Pyrin binds ASC Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Pubmed11498534 Pubmed12615073 Pubmed12667444 Pubmed17964261 Reactome Database ID Release 43877361 Reactome, http://www.reactome.org ReactomeREACT_75855 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06 Trimeric pyrin interacts with ASC through its Pyrin domains, leading to oligomerization of ASC. This interaction interferes with the ability of NLRP3 (Cyropyrin) to associate with ASC and thus inhibits inflammasome activation (Chae et al. 2003). has a Stoichiometric coefficient of 3