IPAF elicitors:NLRC4 IPAF is activated Although a direct interaction between IPAF and an activating ligand has not been demonstrated, IPAF can be activated by cytosolic flagellin either applied experimentally or resulting from the activity of the virulence-associated type III or V secretion systems (Franchi et al. 2006, Miao et al 2007, 2008). Activation can also be flagellin-independent (Suzuki et al. 2007, Sutterwala et al. 2007), suggesting alternative mechanisms that are likely to involve recognition of components of the bacterial type III secretion system (Miao et al. 2010). The LRR domain of IPAF appears to repress activity in the absence of a ligand as removal of this domain leads to constitutive activation (Poyet et al. 2001). Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Pubmed11390368 Pubmed16648852 Pubmed17696608 Pubmed18070936 Pubmed18256184 Pubmed20133635 Reactome Database ID Release 43874084 Reactome, http://www.reactome.org ReactomeREACT_75906 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06 IPAF elicitors