ATP:P2X7 oligomer ATP:P2X7 oligomer:Pannexin-1 P2X7 mediates membrane pores that include pannexin-1 At higher concentrations of extracellular ATP, the P2X7 channel acts as an inducer of nonselective macropores permeable to large (up to 800 Da) inorganic and organic molecules. These 'death complex' pores rapidly leads to complete collapse of ionic gradients, changing the cytosolic environment from high K/ low Na/ low Cl to low K/ high Na/ high Cl (Steinberg et al. 1987, Steinberg & Silverstein 1987, Kahlenberg & Dubyak 2004). The long carboxyl-terminal cytoplasmic domain of P2X7 (352-595) appears to be crucial for P2X7 pore formation (Cheewatrakoolpong et al. 2005, Adinolfi et al. 2005). P2X7 membrane pores were recently shown to include pannexin-1 (Locovei et al. 2007). Pannexins have low homology with the invertebrate innexin gap junction proteins, reported to form gap junction channels and also to function as hemi-gap junction channels that are sensitive to gap junction channel blockers (Bruzzone et al. 2003, 2005). The P2X7 receptor is generally accepted to be part of a multimeric complex, not fully characterized (Kim et al. 2001). Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Pubmed11707406 Pubmed14597722 Pubmed15075209 Pubmed15715654 Pubmed15896293 Pubmed17036048 Pubmed17240370 Pubmed18404507 Pubmed2182768 Pubmed3597398 Pubmed450099 Reactome Database ID Release 43877198 Reactome, http://www.reactome.org ReactomeREACT_75933 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06