SUGT1:HSP90 SGT1 binds HSP90 Authored: Jupe, S, 2010-04-22 Edited: Jupe, S, 2011-04-28 Pubmed14761955 Reactome Database ID Release 43874087 Reactome, http://www.reactome.org ReactomeREACT_75814 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06 The ubiquitin ligase–associated protein SGT1 (SUGT1) has two putative HSP90 binding domains, a tetratricopeptide repeat and a p23-like CHORD and Sgt1 (CS) domain. The CS domain of human SGT1 physically interacts with HSP90. SGT1 and related proteins are believed to recruit heat shock proteins to multiprotein assemblies (Lee et al. 2004).