Thioredoxin:TXNIP TXNIP binds reduced thioredoxin Authored: Jupe, S, 2011-04-15 Edited: Jupe, S, 2011-04-28 Pubmed10419473 Pubmed17603038 Reactome Database ID Release 431250264 Reactome, http://www.reactome.org ReactomeREACT_75760 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06 TXNIP interacts with the redox-active domain of thioredoxin (TRX) and is believed to act as an oxidative stress mediator by inhibiting TRX activity or by limiting its bioavailability (Nishiyama et al. 1999, Liyanage et al. 2007).