TXNIP:NLRP3 TXNIP binds NLRP3 Authored: Jupe, S, 2011-04-28 Edited: Jupe, S, 2011-04-28 Pubmed20023662 Reactome Database ID Release 431250272 Reactome, http://www.reactome.org ReactomeREACT_75932 Reviewed: Kufer, TA, 2011-04-28 Reviewed: Rittinger, K, 2011-06-06 Reviewed: Wong, Edmond, 2011-06-06 Thioredoxin-interacting protein (TXNIP) binds NLRP3. Reactive oxygen species (ROS) such as H2O2 increase this interaction, while the ROS inhibitor APDC blocks it (Zhou et al. 2010). This interaction is proposed to activate the NLRP3 inflammasome.