C3bB iC3 Factor B binds to C3(H2O) Authored: de Bono, B, 2004-08-04 09:17:50 Edited: Jupe, S, 2010-11-17 Pubmed279011 Reactome Database ID Release 43173740 Reactome, http://www.reactome.org ReactomeREACT_8013 Reviewed: D'Eustachio, P, 2006-07-03 21:35:13 Thioester bond hydrolysis causes conformational rearrangements that give C3(H2O) the ability to bind Factor B (Schreiber et al. 1978). The spontaneous hydrolysis rate of C3 under physiological conditions and temperature is about l% per hour, thus the C3b-like properties of C3(H2O) provide a continuous low level initiation of the alternative pathway of complement activation (Pangburn & Muller-Eberhard 1983).