Ligand-independent phosphorylation of overexpressed FGFR1 Authored: Rothfels, K, 2012-02-09 EC Number: 2.7.10 Edited: Rothfels, K, 2012-05-16 FGFR1-amplified lung cancer and breast cancer cells show strong phosphorylation of FGFR1 and do not show elevated levels of FGF ligand, suggesting that these receptors can undergo ligand-independent activation. Phosphorylation is enhanced in the presence of exogenous ligand, supporting the notion that overexpressed FGFR1 can be activated by both ligand- and ligand-independent pathways (Koziczak, 2004; Dutt, 2008; Weiss, 2010). The biochemical consequences of overexpression of FGFR1 in other cancer types remain to be determined (reviewed in Turner and Gross, 2010; Wesche, 2011. Pubmed15116089 Pubmed20094046 Pubmed21160078 Pubmed21666749 Pubmed21711248 Reactome Database ID Release 431982066 Reactome, http://www.reactome.org ReactomeREACT_120931 Reviewed: Ezzat, S, 2012-05-15 has a Stoichiometric coefficient of 16 Overexpressed FGFR1 homodimers Activated overexpressed FGFR1 homodimers