C4b C4b-binding protein C4-binding protein:C4b C4b-binding protein binds C4b Authored: Jupe, S, 2010-10-26 Edited: Jupe, S, 2010-11-01 Pubmed2532155 Pubmed6222381 Pubmed6334079 Pubmed670886 Reactome Database ID Release 43977626 Reactome, http://www.reactome.org ReactomeREACT_118763 Reviewed: Bradley, DT, 2012-02-13 Reviewed: Fraczek, LA, 2012-02-13 The most abundant form of C4b-binding protein (C4BP) consists of seven alpha-chains (70kDa) and one beta-chain (45kDa) all linked by disulphide bonds to form a native protein with a molecular weight of 570kDa (Hilarp et al. 1989). Each alpha chain can bind C4b; it is not known whether full occupancy is necessary for subsequent events. The beta chain binds and inactivates Protein S, a component of the coagulation system. C4BP down-regulates complement activity in several ways: It binds to C4b thus inhibiting the formation of the classical pathway C3 convertase C4bC2a; it acts as a decay accelerating factor for existing convertases, probably by promoting dissociation of C2a; it is a cofactor in Factor I mediated C4b proteolysis. has a Stoichiometric coefficient of 7