Activated FGFR1 fusion mutants FGFR1 fusions bind PLCgamma Authored: Rothfels, K, 2012-02-09 Edited: Rothfels, K, 2012-05-16 FGFR1 fusions with ZMYM2, BCR, FGFR1OP and TRIM24 all result in recruitment and phosphorylation of PLCgamma, and where mutational studies have been performed, mutation of the PLCgamma binding site Y766 has been shown to abrogate this signaling (Guasch, 2001; Roumiantsev, 2004, Lelievre, 2008, Chase, 2007). In the case of BCR-FGFR1 and ZMYM2-FGFR1, mutation of the PLCgamma binding site significantly decreased the transformative phenotype of the FGFR1 fusion (Roumiantsev, 2004). Pubmed11689702 Pubmed15050920 Pubmed17698633 Pubmed18412956 Reactome Database ID Release 431839094 Reactome, http://www.reactome.org ReactomeREACT_121275 Reviewed: Ezzat, S, 2012-05-15 Activated FGFR1 fusion mutants:PLC-gamma