Tyrosine kinase inhibitors of FGFR1 fusion mutants Tyrosine kinase inhibitors bind and inhibit FGFR1 fusion dimer phosphorylation Authored: Rothfels, K, 2012-02-09 Edited: Rothfels, K, 2012-05-16 In a murine mouse model of ZNF198-FGFR1-induced EMS, treatment with the FGFR-inhibitor Midostaurin (PKC412) resulted in prolonged survival (Chen, 2004). Similarly, growth of ZNF-198-FGFR1-, FGFR1OP2-FGFR1-, and BCR-FGFR1-expressing lines is blocked by treatment with FGFR-inhibitors (Demiroglu, 2001; Gu, 2006; Chase, 2007; Zhen, 2007; Wasag, 2011). Pubmed11739186 Pubmed15448205 Pubmed16946300 Pubmed17533378 Pubmed17698633 Pubmed21330321 Reactome Database ID Release 431839039 Reactome, http://www.reactome.org ReactomeREACT_120841 Reviewed: Ezzat, S, 2012-05-15 has a Stoichiometric coefficient of 2 FGFR1 fusion mutant dimers:TKIs FGFR1 fusion mutant dimers