Surface-associated C3bBb Cell surface:FH,FHR3:C3bBb FH, FHR-3 Factor H binds to C3bBb Authored: Jupe, S, 2010-10-26 Edited: Jupe, S, 2010-11-01 Factor H (FH) binds to C3bBb, leading to displacement of Bb. Complement factor H-related protein 3 (FHR-3) has also been reported to bind C3Bb leading to inhibition of C3Bb C3 convertase activity (Fritsche et al. 2010). FH also acts as a cofactor for the factor I-mediated proteolytic inactivation of C3b to iC3b. Pubmed1067618 Pubmed20843825 Pubmed301546 Reactome Database ID Release 43977363 Reactome, http://www.reactome.org ReactomeREACT_118710 Reviewed: Bradley, DT, 2012-02-13 Reviewed: Fraczek, LA, 2012-02-13