TLR6/2 ligand:CD14:CD36 TLR6/2 ligand associates with CD14 and CD36 within lipid rafts Authored: Shamovsky, V, 2012-05-15 Edited: Shamovsky, V, 2012-11-16 Pubmed16880211 Reactome Database ID Release 432559464 Reactome, http://www.reactome.org ReactomeREACT_150409 Reviewed: D'Eustachio, P, 2006-07-03 21:35:13 Reviewed: Gillespie, ME, 2010-11-30 Reviewed: Granucci, Francesca, Zanoni, Ivan, 2012-11-13 Scavenger receptor CD36 has been reported to function as an essential co-receptor involved in recognition of LTA and certain diacylated lipoproteins and presenting them to the TLR2:TLR6 heterodimer at the cell surface. CD14, a GPI-anchored molecule found on the cell surface of human phagocytes, has been also implicated in TLR2:TLR6 signaling [Stuart L et al 2005; Hoebe KP et al 2005; Triantafilou M et al 2006; Nilsen NJ et al 2008] TLR6:TLR2 recognized ligand