MBL-II:MASP-2 dimer:MASP-1 dimer complex MBL bound to mannose-based carbohydrates on bacterial surfaces MBL binds to repetitive carbohydrate structures on the surfaces of viruses, bacteria, fungi, and protozoa Authored: de Bono, B, 2004-08-04 09:17:50 Extracellular MBL oligomer complexed with MASP2 binds to a repetitive carbohydrate motif on a target surface to form a MASP2:MBL oligomer:carbohydrate complex on the surface. Such motifs occur on the surfaces of viruses, bacteria, fungi and protozoa. The affinity of any one MBL binding site for a carbohydrate ligand is low, but interaction between multiple binding sites on an MBL oligomer and a repetitive carbohydrate motif on a target surface allow high-avidity binding. The specificity of the MBL binding site (it does not bind glucose or sialic acid) and the requirement for a repeated target motif may account for the failure of MBL to bind human glycoproteins under normal conditions (Petersen et al. 2001). This reaction in particular represents the interaction of MBL with bacterial mannose repeats. Pubmed10639434 Pubmed11532276 Reactome Database ID Release 43166721 Reactome, http://www.reactome.org ReactomeREACT_7983 Reviewed: D'Eustachio, P, 2006-07-03 21:35:13 has a Stoichiometric coefficient of 4 Bacterial mannose-based carbohydrate surface pattern