IGF2BP3 Binds Specific RNA Molecules Authored: May, B, 2009-07-04 Edited: May, B, 2009-07-04 Insulin-like Growth Factor mRNA Binding Factor-3 (IGF2BP3, also known as IMP3 and VICKZ3) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.<br>Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP3 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive). Pubmed11713986 Pubmed15601260 Pubmed16541107 Pubmed20371350 Pubmed9891060 Reactome Database ID Release 43428287 Reactome, http://www.reactome.org ReactomeREACT_22429 Reviewed: Chao, JA, 2010-05-30 Reviewed: Singer, RH, 2010-05-30 IGF2BP3:RNA Complex RNA molecules bound by IGF2BP3 (IMP3/VICKZ3)