IGF2BP1 Binds Specific RNA Molecules Authored: May, B, 2009-07-04 Edited: May, B, 2009-07-04 Insulin-like Growth Factor mRNA Binding Factor-1 (IGF2BP1, also known as ZBP1, CRD-BP, IMP1, and VICKZ1) binds several specific RNAs containing the sequence motif CAUH (where H is A, C, or U). Binding causes stabilization and subcellular localization of the RNA.<br>Isoforms of IGF2 mRNA containing leader-3 are bound by IGF2BP1 at the 5' UTR, repressing translation (other isoforms of IGF2 are constitutive).<br>ZBP1 (IGF2BP1) uses its third and fourth KH domains to recognize the first 28 nts of the 3? UTR of Beta?actin mRNA. The KH domains are arranged as an anti-parallel pseudo-dimer that specifically recognize a bipartite element located in this RNA sequence.<br>MYC (c-MYC) and Beta-TRCP1 mRNAs are bound at sites termed Coding Region Determinants (CDRs) in the open reading frame of the message. Binding of the MYC mRNA shields it from degradation and increases its half-life<br> The CD44 mRNA is bound at the 3' UTR.<br>IGF2BP1 also binds the non-coding, imprinted H19 RNA. Pubmed10875929 Pubmed11713986 Pubmed12024010 Pubmed12894594 Pubmed15601260 Pubmed16541107 Pubmed16778892 Pubmed17652133 Pubmed19029303 Pubmed20080952 Pubmed20371350 Pubmed9891060 Reactome Database ID Release 43428296 Reactome, http://www.reactome.org ReactomeREACT_22241 Reviewed: Chao, JA, 2010-05-30 Reviewed: Singer, RH, 2010-05-30 IGF2BP1:RNA Complex RNA molecules bound by IGF2BP1 (IMP1/CRD-BP/ZBP1/VICKZ1)