Proteolysis of the IGF:IGFBP-4 Complex by PAPP-A EC Number: 3.4.24 Edited: May, B, Gopinathrao, G, 2008-11-19 20:02:07 Pregnancy associated Plasma Protein A (PPAP-A) cleaves IGFBP-4 in the IGF:IGFBP-4 Complex between amino acids 156 and 157, releasing IGF. Pubmed10077652 Pubmed10898936 Pubmed11158056 Pubmed12241545 Pubmed12379487 Pubmed12466191 Pubmed12904166 Pubmed17047378 Pubmed17249697 Pubmed17312271 Reactome Database ID Release 43381518 Reactome, http://www.reactome.org ReactomeREACT_15447 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 IGF:IGFBP-4 Complex IGF1/2