Proteolysis of the IGF:IGFBP-3:ALS Complex by Prostate-specific Antigen EC Number: 3.4.21 Edited: May, B, Gopinathrao, G, 2008-11-19 20:02:07 Prostate specific Antigen (PSA) cleaves IGFBP-3 in the IGF:IGFBP-3:ALS Complex between amino acids 186 and 187. Other cleavage sites were observed but not reproducibly. These may have been caused by impurities in the PSA preparation. Pubmed10218588 Pubmed11751371 Pubmed12379487 Pubmed12466191 Pubmed1383255 Pubmed17047378 Pubmed7525634 Pubmed7525824 Pubmed7538844 Pubmed8817670 Reactome Database ID Release 43381466 Reactome, http://www.reactome.org ReactomeREACT_15465 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 IGF:IGFBP-3:ALS Complex IGF1/2