Secretion of Acyl Ghrelin and C-Ghrelin Acyl ghrelin and C-ghrelin are secreted from secretory granules into the bloodstream. Five forms of acyl ghrelin have been detected: octanoyl ghrelin-28, decanoyl ghrelin-28, octanoyl ghrelin-27, decanoyl ghrelin-27, and decenoyl ghrelin-28. Unacylated ghrelin (des-acyl ghrelin) occurs at higher levels than acyl ghrelin however its function and mechanism of generation are controversial. The function, if any, of C-ghrelin is also unknown.<br>Secretion of ghrelin is stimulated by insulin-like growth factor-1 and muscarinic agonists; Secretion is inhibited by insulin, somatotropin, leptin, glucose, glucagon, and fatty acids. Carbohydrates have more inhibitory effect than fat does. The mechanisms by which the regulation is effected are unknown. Authored: May, B, 2009-06-10 Edited: May, B, 2009-06-10 Pubmed11089560 Pubmed11600536 Pubmed11756331 Pubmed12354137 Pubmed12553549 Pubmed14599721 Pubmed15126574 Pubmed17595255 Pubmed18396350 Pubmed19280057 Reactome Database ID Release 43422048 Reactome, http://www.reactome.org ReactomeREACT_19136 Reviewed: Zhang, Weizhen, 2009-08-29 Acyl Ghrelin Acyl Ghrelin