Cleavage of Acyl Proghrelin by Prohormone Convertase 1/3 Acyl proghrelin is cleaved by prohormone convertase 1/3 (PC1/3) to yield acyl ghrelin (the N-terminal fragment) and C-ghrelin (the C-terminal fragment). Transfection experiments show that PC1/3 is sufficient to generate acyl ghrelin of 28 amino acid residues (acyl ghrelin-28). Acyl ghrelin of 27 amino acid residues (acyl ghrelin-27) can also be detected in plasma. How acyl ghrelin-27 is generated remains undetermined but it is speculated to derive from the cleavage of arginine-28 from the C-terminus of ghrelin by a carboxypeptidase B-like enzyme. Authored: May, B, 2009-06-10 EC Number: 3.4.21 Edited: May, B, 2009-06-10 Pubmed18396350 Pubmed19280057 Pubmed19628676 Reactome Database ID Release 43422021 Reactome, http://www.reactome.org ReactomeREACT_19170 Reviewed: Zhang, Weizhen, 2009-08-29 Acyl Ghrelin Acyl Proghrelin