FGFR1b FGFR1b binds to FGF Authored: de Bono, B, 2007-01-10 10:27:18 In this reaction, FGF receptor in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. NCAM and other members of the CAM protein family directly or indirectly modulate this interaction in a variety of neural tissues. The details of this interaction in vivo have not been definitively established at the molecular level, but are thought to play a central role in the regulation of the development of these tissues. Pubmed12791257 Pubmed15863029 Pubmed16045455 Pubmed16597617 Pubmed16709412 Pubmed7917292 Reactome Database ID Release 43190245 Reactome, http://www.reactome.org ReactomeREACT_9523 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 has a Stoichiometric coefficient of 2 FGFR1b homodimer bound to FGF FGFR1b-binding FGFs