Decanoylation of Proghrelin by Ghrelin O-acyltransferase Authored: May, B, 2009-06-10 Edited: May, B, 2009-06-10 Proghrelin is decanoylated by ghrelin O-acyltransferase (GOAT/MBOAT4), an enzyme present in the endoplasmic reticulum membrane which both transports the decanoic acid substrate and condenses it on the hydroxyl group of serine-3 of the mature protein. The most common acylated form of ghrelin is octanoyl ghrelin but decanoyl ghrelin is also detected in plasma. GOAT is able to use substrates up to tetradecanoic acid. Ghrelin is the only protein known to undergo such a modification. Pubmed12414809 Pubmed18396350 Pubmed18443287 Pubmed19280057 Pubmed19628676 Reactome Database ID Release 43422017 Reactome, http://www.reactome.org ReactomeREACT_19329 Reviewed: Zhang, Weizhen, 2009-08-29