FGFR2c binds to FGF Authored: de Bono, B, 2007-01-10 10:27:18 In this reaction, FGF receptor 2c in the plasma membrane binds an associating extracellular ligand, a requisite step for subsequent activation. The resulting complex consists of dimerized receptor, two ligand molecules, and heparan sulfate. Two isoforms of FGFR2c generated by alternative splicing and differing only by the presence ("long") or absence ("short") of two amino acid residues at positions 428-429 are equally active in ligand binding and dimerization but differ in their abilities to interact with downstream targets. Pubmed15863029 Pubmed16597617 Reactome Database ID Release 43190258 Reactome, http://www.reactome.org ReactomeREACT_9477 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 has a Stoichiometric coefficient of 2 FGFR2c homodimer bound to FGF FGFR2c-binding FGFs Fibroblast growth factor receptor 2c