Activated FGFR Activated FGFR binds FRS2beta Authored: Rothfels, K, 2011-08-15 FRS2beta is predominantly expressed in the developing and adult neuroepithelium. As is the case for FRS2alpha, binding of FRS2beta to FGFR may be constitutive and/or independent of receptor activation. Elements of the downstream signaling mediated by the two FRS2 family members appear to be at least partially conserved, as FRS2beta is phosphorylated upon FGF stimulation, binds SHP2 and GRB2 and results in ERK activation. Moreover, expression of FRS2beta in FRS2alpha-/- MEFs restores ERK activation. Pubmed10629055 Pubmed15094036 Pubmed19187780 Pubmed9660748 Reactome Database ID Release 431268221 Reactome, http://www.reactome.org ReactomeREACT_111238 Reviewed: Gotoh, N, 2011-08-26 Activated FGFR:FRS2beta