Processing of Proinsulin to Insulin Authored: May, B, 2008-05-13 13:18:27 EC Number: 3.4.17 EC Number: 3.4.21 Edited: May, B, Gopinathrao, G, 2008-11-19 19:22:37 Proinsulin in proinsulin-zinc-calcium complexes is cleaved by endopeptidases Convertase 1/3 and Convertase 2. The exopeptidase Carboxypeptidase E then removes 2 amino acids from the carboxyl termini. Unlike the proinsulin-zinc calcium complex, the insulin-zinc-calcium complex is not soluble and forms crystals inside the secretory granules. Pubmed10521251 Pubmed11462236 Pubmed12136131 Pubmed12595704 Pubmed14617756 Pubmed1528899 Pubmed16158220 Pubmed16984975 Pubmed18180315 Pubmed3896518 Pubmed7626024 Pubmed7822759 Pubmed8916141 Pubmed8947461 Pubmed9166668 Pubmed9207799 Pubmed9631292 Pubmed9667917 Reactome Database ID Release 43265179 Reactome, http://www.reactome.org ReactomeREACT_15374 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 Insulin-Zinc-Calcium Complex Proinsulin-Zinc-Calcium Complex (granule)