Formation of the IGF:IGFBP-3:ALS Complex Edited: May, B, Gopinathrao, G, 2008-11-19 20:02:07 IGFBP 3 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 3. IGFBP 3 also binds ALS via the C terminal portion of IGFBP 3. The interaction is dependent on the glycosylation of ALS.<br>IGFBP 3, which binds most IGF in the body, is enriched in follicular fluid and found in many other tissues. IGFBP 3 may be cleaved by plasmin, thrombin, Prostate specific Antigen (PSA), Matrix Metalloprotease 1, and Matrix Metalloprotease 2. IGFBP 3 also binds extracellular matrix and binding lowers its affinity for IGFs. IGFBP 3 stimulates the effects of IGFs.<br> Pubmed10026136 Pubmed10681634 Pubmed10810289 Pubmed11250653 Pubmed11316783 Pubmed11788658 Pubmed12379487 Pubmed12466191 Pubmed12810533 Pubmed1370451 Pubmed15126567 Pubmed15469690 Pubmed15485880 Pubmed17047378 Pubmed2476804 Pubmed7519608 Pubmed7543116 Pubmed7683646 Pubmed7689487 Pubmed8781553 Pubmed9497324 Pubmed9709957 Reactome Database ID Release 43381496 Reactome, http://www.reactome.org ReactomeREACT_15417 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 IGF:IGFBP-3:ALS Complex IGF1/2