Formation of the IGF:IGFBP-5:ALS Complex Edited: May, B, Gopinathrao, G, 2008-11-19 20:02:07 IGFBP 5 binds IGF I or IGF II via the conserved N terminus and C terminus of IGFBP 5. IGFBP 5 also binds ALS via the central portion of IGFBP 5. About 55% of IGF:IGFBP 5 complexes contain ALS. IGFBP 5 is enriched in bone matrix and acts to stimulate IGF function. IGFBP 5 is cleaved by Pregnancy associated Plasma Protein A2 (PAPP A2), ADAM 9, complement C1s from smooth muscle, and thrombin. Only the cleavage site for PAPP A2 is known. About 55% of IGF:IGFBP 5 complexes contain ALS; 45% contain only IGF and IGFBP 5. Pubmed10614670 Pubmed10810289 Pubmed11316783 Pubmed11788658 Pubmed12379487 Pubmed12466191 Pubmed15126567 Pubmed17047378 Pubmed7519608 Pubmed7683646 Pubmed7689487 Pubmed8781553 Pubmed9497324 Pubmed9786878 Reactome Database ID Release 43381545 Reactome, http://www.reactome.org ReactomeREACT_15355 Reviewed: D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31 IGF:IGFBP-5:ALS Complex IGF1/2