PLC-gamma phosphorylation by FGFR Authored: de Bono, B, 2007-01-10 10:27:18 EC Number: 2.7.10 Edited: Jupe, S, 2010-02-03 PLC gamma is phosphorylated by activated FGFR, resulting in PLC gamma activation, stimulation of phosphatidyl inositol hydrolysis and generation of two second messengers, diacylglycerol and inositol (1,4,5) P3. Tyrosine phosphorylation of PLCgamma by FGFR4 is weaker than that seen by other isoforms of FGFR. Pubmed10579907 Reactome Database ID Release 43190898 Reactome, http://www.reactome.org ReactomeREACT_21329 Reviewed: Mohammadi, M, 2007-02-06 21:44:35 has a Stoichiometric coefficient of 4 Activated FGFR bound to activated PLC gamma Activated FGFR bound to PLC gamma