SHC1 is phosphorylated Authored: Rothfels, K, 2011-08-15 EC Number: 2.7.10 Pubmed18840094 Pubmed7559490 Pubmed8264585 Pubmed9045692 Reactome Database ID Release 431268281 Reactome, http://www.reactome.org ReactomeREACT_111110 Reviewed: Gotoh, N, 2011-08-26 The p46 and p53 isoforms of SHC1 have been shown to be phosphorylated upon FGF stimulation. Three consensus RTK phosphoryation sites are present in SHC1, although phosphorylation of these specific tyrosine residues has not been explicitly demonstrated in response to FGF stimulation. In contrast, the p66 isoform of SHC1 does not appear to undergo FGF-dependent phosphorylation. has a Stoichiometric coefficient of 3 Activated FGFR:p-SHC1 Activated FGFR:SHC1