GRB2:GAB1:PI3Kreg binds directly to p-FRS2:activated FGFR Authored: Rothfels, K, 2011-08-15 Pubmed11353842 Pubmed14534538 Pubmed9182757 Pubmed9632781 Reactome Database ID Release 431268245 Reactome, http://www.reactome.org ReactomeREACT_111163 Reviewed: Gotoh, N, 2011-08-26 The direct GRB2-binding sites of FRS2alpha have a major role in activation of the PI3K pathway. Activated FGFR:p-FRS2alpha Activated FGFR:p-FRS2alpha:GRB2:GAB1:PI3KR1 GRB2:GAB1:PIK3R1