SPRY2 translocates to the plasma membrane Authored: Rothfels, K, 2011-08-15 Pubmed10887178 Pubmed11238463 Pubmed11279012 Pubmed12391162 Reactome Database ID Release 431295599 Reactome, http://www.reactome.org ReactomeREACT_111232 Reviewed: Gotoh, N, 2011-08-26 SPRY2 translocates to the plasma membrane upon activation of cells with FGF, and translocation is required for the inhibition of growth factor-stimulated cell migration, proliferation and differentiation. Translocation may be mediated by interactions with PIP2 in the membrane, palmitoylation of the C-terminal region of SPRY2 and/or interactions with caveolin-1. PPA2A(A:C):SPRY2 PP2A(A:C):SPRY2