SHP2 dephosphorylates SPRY2 Authored: Rothfels, K, 2011-08-15 EC Number: 3.1.3.48 Pubmed15031289 Pubmed17993263 Reactome Database ID Release 431549564 Reactome, http://www.reactome.org ReactomeREACT_111157 Reviewed: Gotoh, N, 2011-08-26 SHP2 may exert its positive effects on MAPK activation in response to FGF stimulation by catalyzing the dephosphorylation of tyrosine resides on SPRY2. This dephosphorylation promotes dissociation of the GRB2/SPRY2 complex and as a consequence stimulates GRB2 association with the activated receptor, leading to sustained MAPK signaling. PPA2A (A:C):Y55/Y227 p-SPRY2:GRB2 PP2A(A:C):Y55/Y227-pSPRY2