Dissociation of p-ERK from p-MEK Authored: Rothfels, K, 2011-08-15 Pubmed15239952 Pubmed8388392 Reactome Database ID Release 431268206 Reactome, http://www.reactome.org ReactomeREACT_111113 Reviewed: Gotoh, N, 2011-08-26 p-ERK1/2 dissociates from p-MEK1/2, allowing dimerization of the activated MAPKs and translocation to the nucleus. In FGFR signaling, there is evidence that this dissociation event is negatively regulated by the golgi membrane form of IL17RD, preventing the nuclear localization of activated ERK1/2. Phospho-ERK p-MEK:p-ERK Phospho-MEK