(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H At the beginning of this reaction, 1 molecule of 'NAD+', and 1 molecule of '(S)-3-Hydroxybutanoyl-CoA' are present. At the end of this reaction, 1 molecule of 'acetoacetyl-CoA', 1 molecule of 'H+', and 1 molecule of 'NADH' are present.<br><br> This reaction takes place in the 'mitochondrial matrix' and is mediated by the '3-hydroxyacyl-CoA dehydrogenase activity' of 'short chain 3-hydroxyacyl-CoA dehydrogenase homodimer'.<br> EC Number: 1.1.1.35 Pubmed10231530 Pubmed8687463 Reactome Database ID Release 4377312 Reactome, http://www.reactome.org ReactomeREACT_447