p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88 :Mal:activated TLR TRAF6 binds to hp- IRAK1 Authored: de Bono, B, 2005-08-16 10:54:15 Edited: Shamovsky, V, 2012-11-06 Hyperphosphorylated IRAK1, still within the receptor complex, binds TRAF6 through multiple regions including the death domain, the undefined domain and the C-terminal C1 domain (Li et al. 2001). The C-terminal region of IRAK-1 contains three potential TRAF6-binding sites; mutation of the amino acids (Glu544, Glu587, Glu706) in these sites to alanine greatly reduces activation of NFkappaB (Ye et al. 2002). Pubmed11287640 Pubmed12138165 Pubmed12140561 Pubmed18070982 Pubmed8837778 Reactome Database ID Release 43166363 Reactome, http://www.reactome.org ReactomeREACT_6856 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Reviewed: Gillespie, ME, 2010-11-30 Reviewed: Napetschnig, Johanna, 2012-11-16 has a Stoichiometric coefficient of 4