TRAF6:hp-IRAK1 p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR receptor TRAF6:hp-IRAK1:p-IRAK4:oligo-MyD88 :Mal:activated TLR Dissociation of hp-IRAK1:TRAF6 from the activated TLR:oligo-Myd88:Mal:p-IRAK4 complex Authored: de Bono, B, 2005-08-16 10:54:15 Edited: Shamovsky, V, 2012-11-06 Hyperphosphorylated IRAK1 and TRAF6 are thought to dissociate from the activated receptor. (Gottipati et al. 2007) but the IRAK1:TRAF6 complex may remain associated with the membrane (Dong et al. 2006).<p> Phosphorylated IRAK2, like its paralog IRAK1, possibly dissociates from the activated receptor as shown here, although mechanism of IRAK2 activation by IRAK4 followed by TRAF6 binding remains to be deciphered. Pubmed14625308 Pubmed16831874 Pubmed17890055 Reactome Database ID Release 43166362 Reactome, http://www.reactome.org ReactomeREACT_6736 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Reviewed: Gillespie, ME, 2010-11-30 Reviewed: Napetschnig, Johanna, 2012-11-16 has a Stoichiometric coefficient of 4