TLR1:TLR2 ligand:CD14 TLR1/2 ligand binds to CD14 Authored: Shamovsky, V, 2012-05-15 CD14, a GPI-anchored molecule found on the cell surface of human phagocytes, has been identified as a co-receptor that interacts with LPS. CD14 has been also implicated in TLR-2 signalling [Hajishengallis G et al 2006; Zivkovic A et al 2011]. Studies have demonstrated that CD14 can bind to triacylated lipoproteins and mediate the activation of the innate immune system trough TLR2:TLR1 complex [Nakata T et al 2006; Manukyan M et al 2005; Triantafilou M et al 2006] Edited: Shamovsky, V, 2012-11-19 Pubmed15714590 Pubmed16880211 Reactome Database ID Release 432559468 Reactome, http://www.reactome.org ReactomeREACT_150261 Reviewed: Granucci, Francesca, Zanoni, Ivan, 2012-11-13 TLR1:TLR2 recognized ligand