MyD88:Mal complexed with the activated TLR activated TLR2/4:p-4Y-MAL:BTK MyD88 forms a complex with MAL:activated TLR2/4 Authored: de Bono, B, 2005-08-16 10:54:15 Edited: Shamovsky, V, 2012-11-06 MyD88 binds to IRAK (IL-1 receptor-associated kinase) and the receptor heterocomplex (the signaling complex) and thereby mediates the association of IRAK with the receptor. MyD88 therefore couples a serine/threonine protein kinase to the receptor complex. Pubmed12447441 Pubmed12447442 Pubmed9430229 Reactome Database ID Release 43166072 Reactome, http://www.reactome.org ReactomeREACT_6797 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Reviewed: Gillespie, ME, 2010-11-30 Reviewed: Napetschnig, Johanna, 2012-11-16 has a Stoichiometric coefficient of 2