MAL:activated TLR2/4 MAL:BTK:activated TLR2/4 Activated TLR2/4:MAL interacts with BTK Authored: Shamovsky, V, 2012-04-19 Bruton's tyrosine kinase (BTK) is a cytoplasmic tyrosine kinase, which plays an essential role in B cell receptor (BCR) signaling [Brunner C et al 2005]. BTK has been also implicated in TLR signaling [Lee KG et al 2012, Jefferies CA et al 2003]. Interaction studies revealed that BTK can associate with intracellular TIR-domains of TLRs 4, 6, 8 and 9. Furthermore, BTK was found to interact with other proteins involved in TLR2/4 signaling - MyD88, MAL and IRAK-1 [Jefferies CA et al 2003]. Edited: Shamovsky, V, 2012-11-06 Pubmed12724322 Pubmed15944945 Pubmed22454496 Reactome Database ID Release 432559414 Reactome, http://www.reactome.org ReactomeREACT_150418 Reviewed: D'Eustachio, P, 2012-05-25 Reviewed: Napetschnig, Johanna, 2012-11-16 has a Stoichiometric coefficient of 2