TLR4:MD2:LPS:CD14 TRAM:TLR4:MD2:LPS:CD14 TLR4:MD2:LPS:CD14 recruits TRAM Authored: de Bono, B, 2005-08-16 10:54:15 Edited: Shamovsky, V, 2011-08-12 Pubmed12471095 Pubmed14556004 Pubmed15596121 Reactome Database ID Release 43166168 Reactome, http://www.reactome.org ReactomeREACT_6808 Reviewed: Gay, NJ, 2006-04-24 16:48:17 Reviewed: Gillespie, ME, 2010-11-30 Reviewed: Granucci, Francesca, Zanoni, Ivan, 2012-11-13 TRIF-related adapter molecule (TRAM, also called TIRP or TICAM-2) is 235 amino acids in length, and its TIR domain is most closely related to TRIF (and hence its name). Notably, both human and mouse TRAM contain a cysteine (C117 in humans) at the position where other adapters and TLRs have a conserved proline, although an adjacent proline (P116) is present. TRAM associates with TLR4 and TRIF, as well as the non-canonical NFkB kinases, IKK epsilon, and TBK1, which phosphorylate IRF3. TRAM provides specificity for the MyD88-independent component of TLR4 signaling. has a Stoichiometric coefficient of 2