IRAK4:oligo-MyD88:Mal:activated TLR p-S,2T-IRAK4:oligo-MyD88:Mal:activated TLR receptor IRAK4 autophosphorylation in the complex with activated TLR:MyD88:Mal Authored: Shamovsky, V, 2010-06-01 EC Number: 2.7.11 Edited: Shamovsky, V, 2012-11-06 IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346. Pubmed17141195 Pubmed17485511 Reactome Database ID Release 43937022 Reactome, http://www.reactome.org ReactomeREACT_25097 Reviewed: Gillespie, ME, 2010-11-30 Reviewed: Napetschnig, Johanna, 2012-11-16 has a Stoichiometric coefficient of 12